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Integrating NGS into Mainstream Laboratory Testing

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Integrating NGS into Mainstream Laboratory Testing

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Scientists started sequencing DNA several years before laboratory information management systems (LIMS) were commercially available in 1982 to help control laboratory processes, track samples, and laboratory workflows and data. In this article we will discuss how work with DNA has advanced to Next Generation Sequencing and how modern laboratory testing can help streamline the process of sequencing DNA, by offering higher quality diagnostics testing and a more effective process.

The first platforms for Next Generation Sequencing (NGS), which emerged at around the start of this century, built upon the Sanger method (amplicon sequencing), but are able to carry out hundreds to millions of sequencing reactions in parallel, together with the analysis of the sequencing data that is being produced. As well as generating massive amounts of data, today’s NGS platforms are incredibly fast and relatively cheap in comparison to earlier applications of DNA sequencing. The costs are continually falling thereby facilitating the use of NGS, which is a form of automated DNA sequencing, for many new applications that just 10 years ago would have been cost-prohibitive. Today, NGS has moved into the healthcare arena, and is used increasingly for clinical diagnostic applications (e.g., diagnostics testing). Commonly used NGS processes, including whole exome sequencing, DNA target-based sequencing, RNA sequencing, and chromatin immunoprecipitation sequencing, are behind the development of innovative processes and discoveries in both research and patient-centered settings.

Eva

Eva

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